When you have SAP Signature theme or Blue crystal theme set in GUI with checkbox "Accept Belize theme" selected, you are not able to set system-specific color for S/4 HANA system.
SAP GUI 750
GUI color, Belize theme, fiori theme, S/4 hana, System specific color, GUI 750 , KBA , BC-FES-GUI , Graphical User Interface , BC-FES-CTL , SAP GUI for Windows Controls , BC-FES-INS , Frontend Installation , Problem
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